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The Silver Spring monkeys were 17 wild-born macaque monkeys from the Philippines who were kept in the Institute of Behavioral Research in Silver Spring, Maryland.〔 From 1981 until 1991, they became what one writer called the most famous lab animals in history, as a result of a battle between animal researchers, animal advocates, politicians, and the courts over whether to use them in research or release them to a sanctuary. Within the scientific community, the monkeys became known for their use in experiments into neuroplasticity—the ability of the adult primate brain to reorganize itself—regarded as one of the most exciting discoveries of the 20th century.〔Doidge, Norman. ''The Brain That Changes Itself''. Viking Penguin, 2007, p. 136: Doidge calls them the most famous lab animals in history. *Blum, Deborah. ''The Monkey Wars''. Oxford University Press, 1995, p. 106.〕 The monkeys had been used as research subjects by Edward Taub, a psychologist, who had cut afferent ganglia that supplied sensation to the brain from their arms, then used arm slings to restrain either the good or deafferented arm to train them to use the limbs they could not feel.〔Doidge 2007, p. 141-2.〕 In May 1981, Alex Pacheco of the animal-rights group People for the Ethical Treatment of Animals (PETA) began working undercover in the lab, and alerted police to what PETA viewed as unacceptable living conditions for the monkeys.〔Pacheco, Alex and Francione, Anna. ("The Silver Spring Monkeys" ) in Singer, Peter. ''In Defense of Animals''. Basil Blackwell, 1985, pp. 135–147. *Also see Boffey, Philip M. ("Animals in the lab: Protests accelerate, but use is dropping" ), ''The New York Times'', October 27, 1981. *The National Institutes of Health initially said that Taub's laboratory was "grossly unsanitary" and suspended his funding, a decision that was later reversed; see Dajer, T. "Monkeying with the Brain", ''Discover'', January 1992, pp. 70–71.〕 In what was the first police raid in the U.S. against an animal researcher, police entered the Institute and removed the monkeys, charging Taub with 17 counts of animal cruelty and failing to provide adequate veterinary care. He was convicted on six counts; five were overturned during a second trial, and the final conviction was overturned on appeal in 1983, when the court ruled that Maryland's animal cruelty legislation did not apply to federally funded laboratories.〔 The ensuing battle over the monkeys' custody saw celebrities and politicians campaign for the monkeys' release, an amendment in 1985 to the Animal Welfare Act, the transformation of PETA from a group of friends into a national movement, the creation of the first North American Animal Liberation Front cell, and the first animal research case to reach the United States Supreme Court.〔Carlson 1991. Schwartz, Jeffrey and Begley, Sharon. ''The Mind and the Brain: Neuroplasticity and the Power of Mental Force''. HarperCollins, 2002, p. 161. *Newkirk, Ingrid. ''Free the Animals''. Lantern Books, 2000, p. xv, says the case triggered the formation of the first North American ALF cell.〕 In July 1991, PETA's application to the Supreme Court for custody was rejected, and days later the last of the monkeys were killed. During the subsequent dissection of the monkeys, it was discovered that significant cortical remapping had occurred, suggesting that being forced to use limbs with no sensory input had triggered changes in their brains' organization.〔Leary, Warren E. ("Renewal of Brain Is Found In Disputed Monkey Tests" ), ''The New York Times'', June 28, 1991.〕 This evidence of the brain's plasticity helped overturn the widely held view that the adult brain cannot reorganize itself in response to its environment.〔Schwartz and Begley 2002, pp. 160, 162.〕 After five years of receiving death threats and being unable to find a research position, Taub was offered a grant by the University of Alabama, where he developed a new form of therapy, based on the concept of neuroplasticity, for people disabled as a result of brain damage. Known as constraint-induced movement therapy, it has helped stroke survivors regain the use of limbs paralysed for many years, and has been hailed by the American Stroke Association as at the forefront of a revolution.〔Schwartz and Begley 2002, p. 160. *Doidge 2007, p. 134. *Also see ("Constraint-Induced Movement Therapy" ), "A Rehab Revolution," ''Stroke Connection Magazine'', September/October 2004.〕 ==Background== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Silver Spring monkeys」の詳細全文を読む スポンサード リンク
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